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CC-6009 oda2-t mt+ [#12c]

Name: CC-6009 oda2-t mt+ [#12c]
SKU: CC-6009
Availability: InStock

$30.00

From Miho Sakato-Antoku, Stephen M King lab, University of Connecticut Health, May 2023

Phenotype: a truncation of the motor domain of outer arm dynein heavy chain γHC

This mutant was obtained by crossing CC-125 and oda2-t ida1 to eliminate an unknown mutation affecting cilia in CC-4439 in addition to oda2-t mutation. Please see Sakato-Antoku and King (2023) for details. It is designated as strain 12c in King lab.

Liu Z, Takazaki H, Nakazawa Y, Sakato M, Yagi T, Yasunaga T, King SM, Kamiya R. Partially functional outer-arm dynein in a novel Chlamydomonas mutant expressing a truncated gamma heavy chain. Eukaryot Cell. 2008 Jul;7(7):1136-45. doi: 10.1128/EC.00102-08. Epub 2008 May 16. PMID: 18487347; PMCID: PMC2446680.

Sakato-Antoku M, King SM. Outer-arm dynein light chain LC1 is required for normal motor assembly kinetics, ciliary stability, and motility. Mol Biol Cell. 2023 Jun 1;34(7):ar75. doi: 10.1091/mbc.E23-03-0104. Epub 2023 May 3. PMID: 37133971; PMCID: PMC10295483.

Locus:
ODA2 [DHC15]
Chromosome:
11
Mutation Information:
Predicted Mutation Effect:

CC-6009 oda2-t mt+ [#12c]

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Banner Photo Credit: Chlamydomonas reinhardtii zygotes were stained for immunofluorescence with anti-acetylated tubulin (green), anti-phospholipase D (red), and DAPI (blue) by Karl F. Lechtreck (University of Georgia) and George B. Witman (University of Massachusetts Medical School).

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