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CC-4422 dhc1b-3 mt+

Name: CC-4422 dhc1b-3 mt+
SKU: CC-4422
Availability: InStock

$30.00

From Benjamin Engel and Wallace Marshall, UCSF, June 28, 2011

This is an A to T transversion at position 12313 of the DHC1b coding sequence that results in an Ile to Phe substitution at amino acid 4105. The mutation was UV-induced in the CC-125 background and the original strain was back-crossed twice to eliminate additional mutations that might have resulted from the UV exposure.

Engel BD, Ishikawa H, Wemmer KA, Geimer S, Wakabayashi K, Hirono M, Craige B, Pazour GJ, Witman GB, Kamiya R, Marshall WF (2012) The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function. J Cell Biol 199:151-167

Shih SM, Engel BD, Kocabas F, Bilyard T, Gennerich A, Marshall WF, Yildiz A (2013) Intraflagellar transport drives flagellar surface motility. ELife 2

Locus:
DHC1b
Chromosome:
6

CC-4422 dhc1b-3 mt+

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Banner Photo Credit: Chlamydomonas reinhardtii zygotes were stained for immunofluorescence with anti-acetylated tubulin (green), anti-phospholipase D (red), and DAPI (blue) by Karl F. Lechtreck (University of Georgia) and George B. Witman (University of Massachusetts Medical School).

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