CC-5538 rib72-835 [progeny 9-1]

$30.00

From Susan Dutcher, Washington University in St. Louis, October 2019

This strain was generated from two rounds of backcrosses of LMJ.RY0402.040835 to CC-125 or CC-124. It was examined by single particle Cryo EM to show loss of RIB72 protein and other proteins. mRNA after the insertion is missing.


Bustamante-Marin XM, Horani A, Stoyanova M, Charng W-L, Bottier M, Sears PR, Daniels LA, Bowen H, Conrad DF, Knowles MR, Ostrowski LE, Zariwala MA, Dutcher SK (2019) Mutation of CFAP57 causes primary ciliary dyskinesia by disrupting the asymmetric targeting of a subset of ciliary inner dynein arms. bioRxiv 773028; doi: https://doi.org/10.1101/773028


  • Locus:
  • RIB72
  • Chromosome:
  • 2
  • Mutation Information:
  • Predicted Mutation Effect: