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CC-6008 dlu1-1 tpg1 [#28]

Name: CC-6008 dlu1-1 tpg1 [#28]
SKU: CC-6008
Availability: InStock

$30.00

From Miho Sakato-Antoku, Stephen M King lab, University of Connecticut Health, May 2023

Phenotype: lacks outer arm dynein light chain LC1; reduced axonemal tubulin polyglutamylation; paromomycin-resistant; mixed population of immotile cells and cells showing twitchy motion or swimming

This mutant was obtained by crossing dlu1-1 (strain 5a, CC-6005) and tpg1 (CC-5245).

Kubo T, Yanagisawa HA, Yagi T, Hirono M, Kamiya R. Tubulin polyglutamylation regulates axonemal motility by modulating activities of inner-arm dyneins. Curr Biol. 2010 Mar 9;20(5):441-5. doi: 10.1016/j.cub.2009.12.058. Epub 2010 Feb 25. PMID: 20188560.

Sakato-Antoku M, King SM. Outer-arm dynein light chain LC1 is required for normal motor assembly kinetics, ciliary stability, and motility. Mol Biol Cell. 2023 Jun 1;34(7):ar75. doi: 10.1091/mbc.E23-03-0104. Epub 2023 May 3. PMID: 37133971; PMCID: PMC10295483.

Locus:
DLU1 [DLU1], TPG1 [FAP267]
Chromosome:
2, 17
Mutation Information:
Predicted Mutation Effect:

CC-6008 dlu1-1 tpg1 [#28]

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Banner Photo Credit: Chlamydomonas reinhardtii zygotes were stained for immunofluorescence with anti-acetylated tubulin (green), anti-phospholipase D (red), and DAPI (blue) by Karl F. Lechtreck (University of Georgia) and George B. Witman (University of Massachusetts Medical School).

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