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CC-6066 TUB2(Δ4E)

Name: CC-6066 TUB2(Δ4E)
SKU: CC-6066
Availability: InStock

$30.00

From Tomohiro Kubo, University of Yamanashi-Japan, August 2023

Phenotype: Impaired swimming motility

Background: tub1(int2)

Origin: Generated by a CRISPR/Cas9 mediated gene editing; a paromomycin-resistant gene cassette was inserted into the intron 2 of TUB1 (Cre12.g542250); a hygromycin-resistant gene cassette was inserted into the region near 3’UTR of TUB2 (Cre12.g549550); atop codon was inserted into TUB2 gene to eliminate four glutamate residues (E439, E440, E441, and E442) in the C-terminus region

Kubo T, Tani Y, Yanagisawa HA, Kikkawa M, Oda T. α- and β-tubulin C-terminal tails with distinct modifications are crucial for ciliary motility and assembly. J Cell Sci. 2023 Aug 15;136(16):jcs261070. doi: 10.1242/jcs.261070. Epub 2023 Aug 17. PMID: 37519241.

CC-6066 TUB2(Δ4E)

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Banner Photo Credit: Chlamydomonas reinhardtii zygotes were stained for immunofluorescence with anti-acetylated tubulin (green), anti-phospholipase D (red), and DAPI (blue) by Karl F. Lechtreck (University of Georgia) and George B. Witman (University of Massachusetts Medical School).

Any opinions, findings, and conclusions or recommendations expressed on this website are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

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