CC-1877 pf28 mt-
$30.00
From David Mitchell, April 1985
Phenotype: impaired motility
The pf28 mutant was isolated in Rosenbaum’s laboratory and was subsequently characterized by Kamiya and others. It is an allele at the ODA2 locus, which corresponds to the gene encoding the outer arm dynein gamma heavy chain. It swims slowly and is defective in backward swimming.
Mitchell DR, Rosenbaum JL (1985) A motile Chlamydomonas flagellar mutant that lacks outer dynein arms. J Cell Biol 100:1228-34
Brokaw CJ, Kamiya R (1987) Bending patterns of Chlamydomonas flagella: IV. Mutants with defects in inner and outer dynein arms indicate differences in dynein arm function. Cell Motil Cytoskeleton 8:68-75
Kamiya R (1988) Mutations at twelve independent loci result in absence of outer dynein arms in Chylamydomonas reinhardtii. J Cell Biol 107:2253-2258
Rupp G, O'Toole E, Gardner LC, Mitchell BF, Porter ME (1996) The sup-pf-2 mutations of Chlamydomonas alter the activity of the outer dynein arms by modification of the gamma-dynein heavy chain. J Cell Biol 135:1853-1865
Ahmed NT, Gao C, Lucker BF, Cole DG, Mitchell DR (2008) ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery. J Cell Biol 183:313-322